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Awarded funding

Chris Inglehearn: Research-informed diagnostic testing and disease modelling to develop treatment options and
improve patient outcomes in Amelogenesis Imperfecta. Major project grant from the Rosetrees Trust awarded to Prof Alan Mighell, Prof Chris Inglehearn and Dr Chris Watson. Ref PGL23/100152, £199,868. June 2024-May 2027.

 

Lorna Dougan: ERC Consolidator Fellowship (UKRI Research Frontier guarantee EP/X023524/1), PI, £1.8M

 

Michelle Peckham: 2024-2027 BBSRC BB/X016471/1. £ 1,088,314.47 (£858,204.51PI): Is CEP290 a vesicle tether at the ciliary base? Joe Cockburn. MP: Co-PI (5% FTE: 1.88 hr.pw) and Colin Johnson (Co-PI), 2023-2026 Kidney Research UK RP_010_20220705, 246K, Developing splice switching oligonucleotides as therapeutics. PI Colin Johnson, Co-PIs, MP, John Ladbury, Steve Evans
2023–2026 Fight for Sight 5206/5207247K Developing splice-switching oligonucleotides as therapeutics for CEP290-related retinal dystrophy in retinal organoid models. PI Colin Johnson, Co-PIs, MP, John Ladbury
2022–2027 Wellcome Trust Investigator Award, 223125/Z/21/Z, Regulatory Mechanisms in Myosins, £1.327 (FEC 2.1M), PI; am also collaborator on a BHF grant (with Katya Ghemlich) which will use iPSCs and organoids - heart model

 

Lucy Stead: Glioma Cortical Organoids Models of Glioblastoma Treatment Response, The Brain Tumour Charity, PIs: Drs Lucy Stead and James Poulter, 01/09/2024 to 31/08/2026, £150,000; Paediatric Glioma Cell Line Resource, Yorkshire's Brain Tumour Charity, PI:Dr Lucy Stead, 01/12/2019 to30/11/2024, £8,000; Gliomodel: A proof of concept study, Yorkshire's Brain Tumour Charity, Yorkshire's Brain Tumour Charity, PI:Dr Lucy Stead, 01/03/2022 to 30/04/2023, £25,000; Establishing an ex vivo preclinical GBM model in Leeds, Yorkshire's Brain Tumour Charity, PI:Dr Lucy Stead, 01/05/2021 to 30/04/2023, £16,320

 

James Poulter: Characterising and targeting Cyclin D in development and disease. £1.2 million; University Academic Fellowship. £50,000; Establishing LEUKOLABS.UK (Leukodystrophy Collaborations UK). £12,000; Characterising and targeting Cyclin D in development and disease (renewal). £600,000; Characterising a suite of models and assay cascades to more accurately investigate treatment response in glioblastoma. £190,000 (Co-I with Lucy Stead); Understanding the link between bone marrow failure and chronic inflammation through the lens of VEXAS syndrome. £1,046,487 (Co-I with Sinisa Savic)

 

John Ladbury: Fight for Sight – “Developing Splice-Switching Oligonucleotides as Therapeutics for CEP290-Related Retinal Dystrophy in Retinal Organoid models”. Co-applicant with C. Johnson, M. Peckham -£250K; Kidney Research UK Research Project Grant – “Developing Splice-Switching Oligonucleotides as Therapeutics for CEP290-Related Renal Ciliopathies in Organoid Models”. Co-applicant with C. Johnson, M. Peckham, S. Evans.

 

Colin A Johnson: 2023-2026 Fight for Sight (5206/5207) “Developing splice-switching oligonucleotides as therapeutics for CEP290-related retinal dystrophy in retinal organoid models”, PI £248k; 2023-2026 Kidney Research UK Research Project Grant (RP_010_20220705) “Developing splice-switching oligonucleotides as therapeutics for CEP290-related renal ciliopathies in organoid models”, PI £246k; 2022-2025 Kidney Research UK PKD Grant (PKD_RP_006_20211124) “Pre-clinical testing of ROCK2 inhibition as a new therapeutic treatment for cystic kidney diseases”, PI £244k; 2020-2025 Wellcome Trust multiuser equipment grant (221542/Z/20/Z) “Focussing on biomedical discovery in the North-East of England: A high-throughput/high-content live imaging system for cells, tissues and small model organisms”, PI £348k; 2020-2024 MRC project grant (MR/T017503/1) “Elucidating splicing factor function and retinal splicing programmes: developing new therapeutic strategies for splicing factor retinitis pigmentosa”, Co-I £1.319M

 

Vas Ponnambalam: 2020-2024 BHF project grant 'Role for CXCL2 chemokine in angiogenesis and re-vascularisation' (Ponnambalam, Harrison, Wheatcroft, Yuldasheva, Riobo del Galdo) PG/19/80/34753

 

Niamh Forde: BBSRC grant The role of microRNAs in the evolution of implantation in mammals BB/X007332/1, £1 Million; Wellcome Trust grant Mitigating against life-course complications of heat stress.227178/Z/23/Z £2 Million DR Virginia Pensabene is Co-I on this; submitted: 2024 Project Title: Generating an International hub to facilitate studying climate change health effects on mother and child Funding Source: MRF Amount Awarded: £100,000 Role of Applicant: PI on this grant Outcome: November 2024 Project Title: Defining the mechanism of mammalian implantation through machine learning and AI Funding Source: Human Frontiers Amount Awarded: US$600,000 Role of Applicant: PI on this grant Outcome: September 2024 Project Title: Unravelling the additive burden of climate change stressors on ART: How heat-stress and environmental pollutants compromise the maternal environment during an embryo transfer cycle. Funding Source: ESHRE Amount Awarded: EURO 250,000 Role of Applicant: PI on this grant Outcome: October 2024

 

Sue Burchill: Oct 2019-Dec 2025 Little Princess Trust. Repurposing of drugs targeting drug resistant self-renewing Ewing’s sarcoma cells to accelerate new treatments into clinical trials to improve outcomes. £286k PI: Sue Burchill;