Publications

Baik SY, Tinning H, Wang D, Forde N. Insulin exposed endometrial epithelial cells cultured in a microfluidic device alters transcripts involved in translation that may contribute to reduced implantation capacity of the endometrium. (2021) doi: https://doi.org/10.1101/2021.12.15.472777

Bem THCD, Tinning H, Vasconcelos EJR, Wang D, Forde N. Endometrium On-a-Chip Reveals Insulin- and Glucose-induced Alterations in the Transcriptome and Proteomic Secretome. Endocrinology. 2021 Jun 1;162(6):bqab054. doi: 10.1210/endocr/bqab054.

Barrow R, Wilkinson JN, He Y, Callaghan M, Brüning-Richardson A, Dunning M, Stead LF. (2022). SpheroidAnalyseR – an online platform for analysing data from 3D spheroids or organoids grown in 96-well plates.

Sarrami-Foroushani A, Lassila T, MacRaild M, Asquith J, Roes KCB, Byrne JV, Frangi AF. In-silico trial of intracranial flow diverters replicates and expands insights from conventional clinical trials. Nat Commun. 2021 Jun 23;12(1):3861. doi: 10.1038/s41467-021-23998-w. PMID: 34162852; PMCID: PMC8222326

Vukicevic AM, Zelic K, Milasinovic D, Sarrami-Foroushani A, Jovicic G, Milovanovic P, Djuric M, Filipovic N, Frangi AF. OpenMandible: An open-source framework for highly realistic numerical modelling of lower mandible physiology. Dent Mater. 2021 Apr;37(4):612-624. doi: 10.1016/j.dental.2021.01.009. Epub 2021 Feb 16. PMID: 33602549

Huang Z, Lei H, Chen G, Frangi AF, Xu Y, Elazab A, Qin J, Lei B. Parkinson's Disease Classification and Clinical Score Regression via United Embedding and Sparse Learning From Longitudinal Data. IEEE Trans Neural Netw Learn Syst. 2021 Feb 3;PP. doi: 10.1109/TNNLS.2021.3052652. Epub ahead of print. PMID: 33534713

Abadi E, Segars WP, Tsui BMW, Kinahan PE, Bottenus N, Frangi AF, Maidment A, Lo J, Samei E. Virtual clinical trials in medical imaging: a review. J Med Imaging (Bellingham). 2020 Jul;7(4):042805. doi: 10.1117/1.JMI.7.4.042805. Epub 2020 Apr 11. PMID: 32313817; PMCID: PMC7148435

Lassila T, Sarrami-Foroushani A, Hejazi S, Frangi AF. Population-specific modelling of between/within-subject flow variability in the carotid arteries of the elderly. Int J Numer Method Biomed Eng. 2020 Jan;36(1):e3271. doi: 10.1002/cnm.3271. Epub 2019 Nov 27. PMID: 31691518

Farzi M, Pozo JM, McCloskey E, Eastell R, Harvey N, Wilkinson JM, Frangi AF. A Spatio-Temporal Ageing Atlas of the Proximal Femur. IEEE Trans Med Imaging. 2020 May;39(5):1359-1368. doi: 10.1109/TMI.2019.2945219. Epub 2019 Oct 23. PMID: 31647421

Sarrami-Foroushani A, Lassila T, Hejazi SM, Nagaraja S, Bacon A, Frangi AF. A computational model for prediction of clot platelet content in flow-diverted intracranial aneurysms. J Biomech. 2019 Jun 25;91:7-13. doi: 10.1016/j.jbiomech.2019.04.045. Epub 2019 May 9. PMID: 31104921

Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein R, Mehrotra S, Farkas M, Hilgen G, White K, Pan KT, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Przyborski S, Zwolinski S, Al-Aama J, Alharthi S, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali RR, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Lührmann R, Grellscheid SN, Johnson CA, Lako M. (2018). Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nat Commun 9:4234

Krzisch M, Yuan B, Chen W, Osaki T, Fu D, Garrett-Engele C, Svoboda D, Andrykovich K, Sur M, Jaenisch R. (2023).The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microglia. Biol Psychiatry S0006-3223(24)01459-8. doi: 10.1016/j.biopsych.2024.07.011. Online ahead of print. PMID: 39029776

Atkinson R, Georgiou M, Yang C, Szymanska K, Lahat A, Vasconcelos EJR, Ji Y, Moya Molina M, Collin J, Queen R, Dorgau B, Watson A, Kurzawa-Akanbi M, Laws R, Saxena A, Shyan Beh C, Siachisumo C, Goertler F, Karwatka M, Davey T, Inglehearn CF, McKibbin M, Lührmann R, Steel DH, Elliott DJ, Armstrong L, Urlaub H, Ali RR, Grellscheid SN, Johnson CA, Mozaffari-Jovin S, Lako M. PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. Nat Commun. 2024 Apr 11;15(1):3138. doi: 10.1038/s41467-024-47253-0. PMID: 38605034; PMCID: PMC11009313.

Kpeglo D, Hughes MDG, Dougan L, Haddrick M, Knowles MA, Evans SD, Peyman SA. Modeling the mechanical stiffness of pancreatic ductal adenocarcinoma. Matrix Biol Plus. 2022 Mar 21;14:100109. doi: 10.1016/j.mbplus.2022.100109. PMID: 35399702; PMCID: PMC8990173.

Casas-Mao D, Carrington G, Pujol MG, Peckham M. Effects of specific disease mutations in non-muscle myosin 2A on its structure and function. J Biol Chem. 2024 Jan;300(1):105514. doi: 10.1016/j.jbc.2023.105514. Epub 2023 Nov 30. PMID: 38042490; PMCID: PMC10770755.

Carrington G, Fatima U, Caramujo I, Lewis T, Casas-Mao D, Peckham M. A multiscale approach reveals the molecular architecture of the autoinhibited kinesin KIF5A. J Biol Chem. 2024 Mar;300(3):105713. doi: 10.1016/j.jbc.2024.105713. Epub 2024 Feb 1. PMID: 38309508; PMCID: PMC10907169.

Parker F, Tang AAS, Rogers B, Carrington G, Dos Remedios C, Li A, Tomlinson D, Peckham M. Affimers targeting proteins in the cardiomyocyte Z-disc: Novel tools that improve imaging of heart tissue. Front Cardiovasc Med. 2023 Feb 14;10:1094563. doi: 10.3389/fcvm.2023.1094563. PMID: 36865889; PMCID: PMC9971620.

Carrington G, Hau A, Kosta S, Dugdale HF, Muntoni F, D'Amico A, Van den Bergh P, Romero NB, Malfatti E, Vilchez JJ, Oldfors A, Pajusalu S, Õunap K, Giralt-Pujol M, Zanoteli E, Campbell KS, Iwamoto H, Peckham M, Ochala J. Human skeletal myopathy myosin mutations disrupt myosin head sequestration. JCI Insight. 2023 Nov 8;8(21):e172322. doi: 10.1172/jci.insight.172322. PMID: 37788100; PMCID: PMC10721271.

Saleban M, Harris EL, Poulter JA. D-Type Cyclins in Development and Disease. Genes (Basel). 2023 Jul 14;14(7):1445. doi: 10.3390/genes14071445. PMID: 37510349; PMCID: PMC10378862.

Tanner G, Barrow R, Ajaib S, Al-Jabri M, Ahmed N, Pollock S, Finetti M, Rippaus N, Bruns AF, Syed K, Poulter JA, Matthews L, Hughes T, Wilson E, Johnson C, Varn FS, Brüning-Richardson A, Hogg C, Droop A, Gusnanto A, Care MA, Cutillo L, Westhead DR, Short SC, Jenkinson MD, Brodbelt A, Chakrabarty A, Ismail A, Verhaak RGW, Stead LF. IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy. Genome Biol. 2024 Feb 7;25(1):45. doi: 10.1186/s13059-024-03172-3. PMID: 38326875; PMCID: PMC10848526.

Barry A, Samuel SF, Hosni I, Moursi A, Feugere L, Sennett CJ, Deepak S, Achawal S, Rajaraman C, Iles A, Wollenberg Valero KC, Scott IS, Green V, Stead LF, Greenman J, Wade MA, Beltran-Alvarez P. Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system. Lab Chip. 2023 May 30;23(11):2664-2682. doi: 10.1039/d3lc00204g. PMID: 37191188.

Barrow R, Wilkinson JN, He Y, Callaghan M, Brüning-Richardson A, Dunning M, Stead LF. SpheroidAnalyseR-an online platform for analyzing data from 3D spheroids or organoids grown in 96-well plates. J Biol Methods. 2022 Nov 23;9(4):e163. doi: 10.14440/jbm.2022.388. PMID: 36992918; PMCID: PMC10040300.

Golebiewska A, Hau AC, Oudin A, Stieber D, Yabo YA, Baus V, Barthelemy V, Klein E, Bougnaud S, Keunen O, Wantz M, Michelucci A, Neirinckx V, Muller A, Kaoma T, Nazarov PV, Azuaje F, De Falco A, Flies B, Richart L, Poovathingal S, Arns T, Grzyb K, Mock A, Herold-Mende C, Steino A, Brown D, May P, Miletic H, Malta TM, Noushmehr H, Kwon YJ, Jahn W, Klink B, Tanner G, Stead LF, Mittelbronn M, Skupin A, Hertel F, Bjerkvig R, Niclou SP. Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology. Acta Neuropathol. 2020 Dec;140(6):919-949. doi: 10.1007/s00401-020-02226-7. Epub 2020 Oct 3. PMID: 33009951; PMCID: PMC7666297.

da Silva B, Irving BK, Polson ES, Droop A, Griffiths HBS, Mathew RK, Stead LF, Marrison J, Williams C, Williams J, Short SC, Scarcia M, O'Toole PJ, Allison SJ, Mavria G, Wurdak H. Chemically induced neurite-like outgrowth reveals a multicellular network function in patient-derived glioblastoma cells. J Cell Sci. 2019 Oct 10;132(19):jcs228452. doi: 10.1242/jcs.228452. PMID: 31515278.

King HO, Brend T, Payne HL, Wright A, Ward TA, Patel K, Egnuni T, Stead LF, Patel A, Wurdak H, Short SC. RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells. Stem Cell Reports. 2017 Jan 10;8(1):125-139. doi: 10.1016/j.stemcr.2016.12.005. PMID: 28076755; PMCID: PMC5233453.

King A, Maisey T, Harris EL, Poulter JA, Jayne DG, Khot MI. The contradictory role of febuxostat in ABCG2 expression and potentiating hypericin-mediated photodynamic therapy in colorectal cancers. Photochem Photobiol Sci. 2024 Jun;23(6):1067-1075. doi: 10.1007/s43630-024-00575-w. Epub 2024 Apr 16. PMID: 38625651.

Vig A, Poulter JA, Ottaviani D, Tavares E, Toropova K, Tracewska AM, Mollica A, Kang J, Kehelwathugoda O, Paton T, Maynes JT, Wheway G, Arno G; Genomics England Research Consortium; Khan KN, McKibbin M, Toomes C, Ali M, Di Scipio M, Li S, Ellingford J, Black G, Webster A, Rydzanicz M, Stawiński P, Płoski R, Vincent A, Cheetham ME, Inglehearn CF, Roberts A, Heon E. DYNC2H1 hypomorphic or retina-predominant variants cause nonsyndromic retinal degeneration. Genet Med. 2020 Dec;22(12):2041-2051. doi: 10.1038/s41436-020-0915-1. Epub 2020 Aug 5. PMID: 32753734; PMCID: PMC7708302.

Farooq A, Wood CD, Ladbury JE, Evans SD. On-chip Raman spectroscopy of live single cells for the staging of oesophageal adenocarcinoma progression. Sci Rep. 2024 Jan 19;14(1):1761. doi: 10.1038/s41598-024-52079-3. PMID: 38242991; PMCID: PMC10799027.

Ketchen SE, Gamboa-Esteves FO, Lawler SE, Nowicki MO, Rohwedder A, Knipp S, Prior S, Short SC, Ladbury JE, Brüning-Richardson A. Drug Resistance in Glioma Cells Induced by a Mesenchymal-Amoeboid Migratory Switch. Biomedicines. 2021 Dec 22;10(1):9. doi: 10.3390/biomedicines10010009. PMID: 35052688; PMCID: PMC8773151.

Bourn MD, Mohajerani SZ, Mavria G, Ingram N, Coletta PL, Evans SD, Peyman SA. Tumour associated vasculature-on-a-chip for the evaluation of microbubble-mediated delivery of targeted liposomes. Lab Chip. 2023 Mar 14;23(6):1674-1693. doi: 10.1039/d2lc00963c. PMID: 36779251; PMCID: PMC10013341.

Georgiou M, Yang C, Atkinson R, Pan KT, Buskin A, Molina MM, Collin J, Al-Aama J, Goertler F, Ludwig SEJ, Davey T, Lührmann R, Nagaraja-Grellscheid S, Johnson CA, Ali R, Armstrong L, Korolchuk V, Urlaub H, Mozaffari-Jovin S, Lako M. Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient-induced pluripotent stem cell-derived retinal pigment epithelium cells. Clin Transl Med. 2022 Mar;12(3):e759. doi: 10.1002/ctm2.759. PMID: 35297555; PMCID: PMC8926896.

Ghuloum FI, Stevens LA, Johnson CA, Riobo-Del Galdo NA, Amer MH. Towards modular engineering of cell signalling: Topographically-textured microparticles induce osteogenesis via activation of canonical hedgehog signalling. Biomater Adv. 2023 Nov;154:213652. doi: 10.1016/j.bioadv.2023.213652. Epub 2023 Oct 10. PMID: 37837904.

Roundhill EA, Chicon-Bosch M, Jeys L, Parry M, Rankin KS, Droop A, Burchill SA. RNA sequencing and functional studies of patient-derived cells reveal that neurexin-1 and regulators of this pathway are associated with poor outcomes in Ewing sarcoma. Cell Oncol (Dordr). 2021 Oct;44(5):1065-1085. doi: 10.1007/s13402-021-00619-8. Epub 2021 Aug 17. PMID: 34403115; PMCID: PMC8516792.